Root cause analysis and personalized treatment for recurrent implantation failure.
From embryo implantation to pregnancy, various factors including
embryo quality, uterine and endometrial environment, and blood circulation play a role.
If implantation failure repeats despite transferring good embryos,
rather than simply repeating transfers, re-evaluating potential causes may be necessary.
At Sarang-i Women's Clinic, we review previous tests and procedures,
and plan the treatment direction together based on test results and future pregnancy plans.
The implantation process involves embryo development, uterine cavity structure,
endometrial condition, hormones, and overall health.
If repeated transfer failures have occurred, reviewing previous treatment records is important.
We review the embryo stage, morphology,
and transfer conditions.
The embryo and endometrium must interact
at the right timing.
We review cumulative treatment history rather than a single failure.
We plan necessary tests and next transfer
tailored to individual conditions.
Rather than adding all tests at once, we selectively examine necessary areas based on previous IVF and embryo transfer records.
We review the woman's age, embryo development stage, morphology, number of embryos used, and results from previous transfers.
In certain situations, couple karyotyping or preimplantation genetic testing (PGT) may be discussed.
We confirm the embryo stage and development status.
Previous transfer count and embryo conditions are reviewed.
Embryo chromosomal abnormality risk by age is considered.
PGT application is discussed when needed.
We check for uterine septum, endometrial polyps, submucosal fibroids, uterine adhesions, and hydrosalpinx.
Any new changes since previous examinations are also evaluated.
Structural issues like polyps, fibroids, adhesions are checked.
Uterine shape can be evaluated in more detail if needed.
May be considered when ultrasound findings are abnormal.
Tubal status is additionally confirmed when suspected.
We re-evaluate whether endometrial thickness and preparation were adequate during transfer cycles.
If the endometrium was repeatedly thin or chronic endometritis is suspected,
additional evaluation may be considered.
Previous transfer cycle thickness is re-confirmed.
Hormone use and transfer timing are reviewed.
Selective evaluation when suspected.
Adhesion possibility is checked if endometrium is thin.
Basic endocrine status including thyroid function can be checked.
When personal or family thrombotic risk factors exist,
antiphospholipid antibody and related tests may be considered.
Thyroid function can be checked during ART.
Current diseases and medications are reviewed.
Related tests are considered when risk factors exist.
Smoking, weight, and pregnancy-related health factors are reviewed.
We review the woman's age, embryo development stage, morphology, number of embryos used, and results from previous transfers.
In certain situations, couple karyotyping or preimplantation genetic testing (PGT) may be discussed.
We confirm the embryo stage and development status.
Previous transfer count and embryo conditions are reviewed.
Embryo chromosomal abnormality risk by age is considered.
PGT application is discussed when needed.
We check for uterine septum, endometrial polyps, submucosal fibroids, uterine adhesions, and hydrosalpinx.
Any new changes since previous examinations are also evaluated.
Structural issues like polyps, fibroids, adhesions are checked.
Uterine shape can be evaluated in more detail if needed.
May be considered when ultrasound findings are abnormal.
Tubal status is additionally confirmed when suspected.
We re-evaluate whether endometrial thickness and preparation were adequate during transfer cycles.
If the endometrium was repeatedly thin or chronic endometritis is suspected,
additional evaluation may be considered.
Previous transfer cycle thickness is re-confirmed.
Hormone use and transfer timing are reviewed.
Selective evaluation when suspected.
Adhesion possibility is checked if endometrium is thin.
Basic endocrine status including thyroid function can be checked.
When personal or family thrombotic risk factors exist,
antiphospholipid antibody and related tests may be considered.
Thyroid function can be checked during ART.
Current diseases and medications are reviewed.
Related tests are considered when risk factors exist.
Smoking, weight, and pregnancy-related health factors are reviewed.
Not all additional tests or procedures are performed at once for recurrent implantation failure.
When correctable uterine abnormalities, thin endometrium, or chronic endometritis are suspected,
causes are confirmed and treatment decisions are made. Embryo strategies are also individually planned based on age and previous embryo development results.
Rather than adding all tests at once, necessary areas are selectively examined based on previous procedure records and test results. Embryo quality, uterine cavity structure, endometrial environment, and overall health are checked step by step.
PGT is not mandatory in all cases. Its application is individually discussed considering the woman's age, previous embryo development results, and number of repeated implantation failures.
When chronic endometritis is suspected, it can be confirmed through endometrial biopsy. It is not uniformly performed on all recurrent implantation failure patients but considered when clinically indicated.
Even with recurrent implantation failure, the next transfer can be planned while identifying causes and managing correctable factors. Treatment direction is determined by comprehensively considering the woman's age, remaining embryo quality, and uterine environment.
At Sarang-i, all physicians are experts in IVF procedures
with extensive clinical and research experience.
